General Information

  • ID:  hor006898
  • Uniprot ID:  P05112??26-153)
  • Protein name:  Interleukin-4
  • Gene name:  CCL3; G0S19-1, MIP1A, SCYA3;
  • Organism:  Homo sapiens
  • Family:  IL-4/IL-13 family
  • Source:  Human
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Eukaryota; Opisthokonta; Metazoa; Eumetazoa; Bilateria; Deuterostomia; Chordata; Craniata; Vertebrata; Gnathostomata (jawed vertebrates); Teleostomi; Euteleostomi; Sarcopterygii; Dipnotetrapodomorpha; Tetrapoda; Amniota; Mammalia; Theria; Eutheria; Boreoeutheria; Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini; Hominoidea (apes); Hominidae (great apes); Homininae; Homo; Homo sapiens (Human)
  • GO MF:  NA
  • GO BP:  GO:0005136 interleukin-4 receptor binding; GO:0008083 growth factor activity; GO:0005125 cytokine activity
  • GO CC:  GO:0030890 positive regulation of B cell proliferation; GO:0045191 regulation of isotype switching; GO:0042325 regulation of phosphorylation; GO:0042110 T cell activation; GO:0042092 type 2 immune response; GO:0008203 cholesterol metabolic process; GO:2001171 positive regulation of ATP biosynthetic process; GO:1900223 positive regulation of amyloid-beta clearance; GO:0150076 neuroinflammatory response; GO:0032720 negative regulation of tumor necrosis factor production; GO:0000122 negative regulation of transcription by RNA polymerase II; GO:0045671 negative regulation of osteoclast differentiation; GO:0150079 negative regulation of neuroinflammatory response; GO:0050728 negative regulation of inflammatory response; GO:0050776 regulation of immune response; GO:0010633 negative regulation of epithelial cell migration; GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein; GO:2000553 positive regulation of T-helper 2 cell cytokine production; GO:0030335 positive regul

Sequence Information

  • Sequence:  KCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
  • Length:  128
  • Propeptide:  MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
  • Signal peptide:  MGLTSQLLPPLFFLLACAGNFVHG
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    NA

Physical Information

Mass: Formula:
Absent amino acids: Common amino acids:
pI: Basic residues:
Polar residues: Hydrophobic residues:
Hydrophobicity: Boman Index:
Half-Life: Half-Life Yeast:
Half-Life E.Coli: Aliphatic Index
Instability Index: Extinction Coefficient cystines:
Absorbance 280nm:

Literature

  • PubMed ID:  NA
  • Title:  NA